# 使用 Homebrew, Nix 安装 blast 查看 blast 的安装路径、可执行文件、元数据以及面向 AI 代理工作流的安全说明。 ## 安装 ```sh sudo av install brew:blast ``` 其他安装命令: ### macOS - Homebrew (100%): ```sh brew install blast ``` 证据: local Homebrew formula metadata ### Linux - Nix (92%): ```sh nix profile install nixpkgs#blast ``` 证据: nixpkgs package indexes: pkgs/by-name/bl/blast/package.nix from https://api.github.com/repos/NixOS/nixpkgs/git/trees/master?recursive=1 ## 软件包事实 - **软件包键:** brew:blast - **软件包管理器:** Homebrew - **版本:** 2.17.0 - **来源摘要:** Basic Local Alignment Search Tool - **主页:** - **最后更新:** 2026-06-22T14:02:53-07:00 - **已生成:** 2026-08-03T19:37:03+00:00 ## 可执行文件 - blast_formatter (别名) - blastdb_aliastool (别名) - blastdb_convert (别名) - blastdb_path (别名) - blastdbcheck (别名) - blastdbcmd (别名) - blastdbcp (别名) - blastn (别名) - blastp (别名) - blastx (别名) - cleanup-blastdb-volumes.py (别名) - convert2blastmask (别名) - datatool (别名) - deltablast (别名) - dustmasker (别名) - gc_cli (别名) - get_species_taxids.sh (别名) - legacy_blast.pl (别名) - lmdbxx_sample (别名) - makeblastdb (别名) - makeclusterdb (别名) - makembindex (别名) - makeprofiledb (别名) - project_tree_builder (别名) - psiblast (别名) - rpsblast (别名) - rpstblastn (别名) - run_with_lock (别名) - seedtop (别名) - segmasker (别名) - seqdb_demo (别名) - seqdb_perf (别名) - tax4blast (别名) - tblastn (别名) - tblastx (别名) - update_blastdb.pl (别名) - windowmasker (别名) - windowmasker_2.2.22_adapter.py (别名) ## 安装行为 - Bottle: 不可用 ## 版本和新鲜度 - 页面生成时间: 2026-08-03 - 管理器版本: 2.17.0 ## 项目历史与用法 BLAST, the Basic Local Alignment Search Tool, is one of the defining command-line programs of computational biology. It became the everyday sequence-search utility for comparing DNA and protein sequences against large databases, first through NCBI services and then through local command-line installations. ### 项目历史 NCBI's BLAST help references the 1990 Altschul, Gish, Miller, Myers, and Lipman paper that introduced the Basic Local Alignment Search Tool. The same NCBI reference list traces later BLAST-family milestones including gapped BLAST and PSI-BLAST in 1997, MegaBLAST indexing work in 2008, BLAST+ architecture in 2008, DELTA-BLAST in 2012, Magic-BLAST in 2019, and ElasticBLAST in 2023. The command-line package distributed today is BLAST+, documented by NCBI's BLAST Command Line Applications User Manual. The developer information page identifies BLAST as public-domain software and points developers to the NCBI C++ Toolkit implementation, matching the public GitHub toolkit repository used for source distribution. ### 采用历史 BLAST became a standard because it joined a fast heuristic alignment algorithm with NCBI's growing public sequence databases. Web BLAST made ad hoc searches accessible, while the command-line applications let labs, sequencing centers, and pipelines run repeatable local searches against custom databases. Package-manager adoption reflects that role: even when the upstream distribution is from NCBI rather than a typical single-purpose GitHub project, package managers keep `blastn`, `blastp`, `blastx`, `makeblastdb`, `blastdbcmd`, and related executables available as system tools for bioinformatics workflows. ### 使用方式 Common local workflows build a database with `makeblastdb`, search it with tools such as `blastn` or `blastp`, inspect databases with `blastdbcmd`, and format results with `blast_formatter`. NCBI also documents REST access for programmatic searches against hosted services. The package contains a family of executables rather than one command. That matters for reproducible science because database construction, masking, protein-vs-nucleotide search modes, profile searches, and output formatting are split into scriptable tools. ### 为什么软件包爱好者会关心 For package nerds, BLAST is a canonical example of scientific infrastructure as a Unix package: many binaries, public-domain licensing, local database files, environment/config conventions, and a manual that is closer to laboratory protocol than app documentation. It is also a reminder that the most important command-line tools are not always developer tools. BLAST made local compute a practical front end to public biological databases, so packaging it well directly affected how biology labs automated sequence analysis. ### 时间线 - 1990: Original BLAST paper published. - 1997: Gapped BLAST and PSI-BLAST paper published. - 2008: NCBI BLAST Command Line Applications User Manual citation date and BLAST+ architecture paper appear. - 2012: DELTA-BLAST paper published. - 2019: Magic-BLAST paper published. - 2023: ElasticBLAST cloud-search paper published. ### Related projects - Related projects and descendants include PSI-BLAST, MegaBLAST, DELTA-BLAST, Magic-BLAST, ElasticBLAST, the NCBI C++ Toolkit, FASTA-family sequence search tools, and downstream workflow systems that wrap BLAST searches. ### 来源 - - - - ## 安全说明 infrastructure mutation or orchestration signal. - **Geiger 风险:** orange / 中 - infrastructure mutation or orchestration signal ## Configuration and credential file locations These source-backed paths show where this package keeps local settings or durable credentials. Automic Vault can use them as review targets for secret scanning, migration, and command approval. ## Configuration files - Unix: .ncbirc, ~/.ncbirc, $NCBI/.ncbirc, /etc/.ncbirc - Windows: ncbi.ini, %USERPROFILE%\ncbi.ini, %NCBI%\ncbi.ini, %SYSTEMROOT%\ncbi.ini ## 其他软件包管理器记录 - Nix - blast: normalized package name match | nixpkgs package indexes: pkgs/by-name/bl/blast/package.nix from https://api.github.com/repos/NixOS/nixpkgs/git/trees/master?recursive=1 ## Combined YAML source View the package source record on GitHub. [combined/blast.yml](https://github.com/mxcl/pkgdb/blob/main/combined/blast.yml) ## 来源 - pkg.so package database - Geiger risk classifier - curated configuration and credential file locations - curated package history - pkgdb category and tag curation - external package-manager database matches - cross-ecosystem install command graph