macOS
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brew install ropebwt3local Homebrew formula metadata
brew / rank 9628
Install ropebwt3 with Homebrew
BWT construction and search. Version 3.10 via Homebrew; verified 2026-09-12.
install
Additional install commands
overview
Package summary
BWT construction and search
Project links
Commands and aliases
- ropebwt3
history
Project history and usage
ropebwt3 constructs run-length-encoded Burrows-Wheeler Transform/FM-index data structures for large DNA sequence sets and searches them for exact matches, local alignments, and haplotype diversity.
Project history
Heng Li developed ropebwt3 as a successor in the ropeBWT line for construction and searching of FM-indexes over large, highly redundant DNA collections.
A 2024 Bioinformatics paper described BWT construction and search at terabase scale. Subsequent 3.x releases expanded search and alignment behavior.
Adoption history
ropebwt3 is distributed through Homebrew. The project also supplies downloadable prebuilt indexes for bacterial and human pangenomic data, supporting practical use beyond source builds.
How it is used
Typical workflows build an FMR or FMD index from FASTA/FASTQ data, generate a sampled suffix array, and use `mem`, `sw`, or `hapdiv` for sequence search and alignment.
It is optimized for redundant collections such as pangenomes and high-coverage reads rather than routine high-throughput read alignment.
Why package nerds care
The package brings terabase-scale pangenome indexing to a conventional command-line installation workflow. Its distinction between dynamic FMR files for construction and compact, memory-mappable FMD files for search is particularly relevant to performance-conscious bioinformatics users.
Timeline
- 2024: The ropebwt3 terabase-scale methods paper appeared in Bioinformatics.
- 2025: Version 3.10 added multi-position output to the `sw` command and updated suffix-array construction code.
Related projects
- ropebwt2 is the earlier incremental FM-index construction project.
- The software incorporates a revised BWA-SW approach for local alignment and interoperates with tools such as seqtk when preparing index metadata.
Sources
- https://github.com/lh3/ropebwt3#readme
- https://github.com/lh3/ropebwt3/releases
- source_facts.package-manager
security posture
Risk level: green
narrow executable package without higher-risk signals.
Risk classifier
green risk · low confidence · appliance
Why
- narrow executable package without higher-risk signals
Signals
- metadata:no-higher-risk-signals
Install behavior
- No Homebrew post-install hook is recorded in formula metadata.
- Homebrew bottle metadata is available for 6 platform targets.
- Installs with 1 runtime dependencies.
Recommended review
Before unattended agent use, check whether the tool reads plaintext credentials, writes remote state, publishes artifacts, or shells out to plugins.
executables
Installed executables
| Command | Kind | Exposure | Note |
|---|---|---|---|
ropebwt3 | cli | global executable |
freshness
Version and freshness
These signals separate page generation age, package-manager activity, and upstream release comparison. Version lag is warned only when an evidence URL and comparable versions are present.
page generated2026-09-19
manager version3.10
manager updated2026-09-12
local dataok
upstreamcurrent
latest detectedv3.10
https://github.com/lh3/ropebwt3
- okNo freshness warnings were generated.
install metadata
Package metadata
| Package key | brew:ropebwt3 |
|---|---|
| Version | 3.10 |
| Package manager | Homebrew |
| Package manager page | https://formulae.brew.sh/formula/ropebwt3 |
| Homepage | https://github.com/lh3/ropebwt3 |
| Repository | https://github.com/lh3/ropebwt3 |
| License | MIT AND Apache-2.0 |
| Source archive | https://github.com/lh3/ropebwt3/archive/refs/tags/v3.10.tar.gz |
| Last updated | 2026-09-12T11:02:20Z |
| Pulse | updated |
| Dependencies | libomp |
| Bottle | available (on arm64_linux, arm64_sequoia, arm64_sonoma, arm64_tahoe, sonoma, x86_64_linux) |
| Homebrew post-install | not defined |
| Service | none declared |
registry facts
Source database details
| Source Database | Homebrew formula API |
|---|---|
| Tap | homebrew/core |
| Full Name | ropebwt3 |
| Version Scheme | 0 |
| Revision | 0 |
| Head Version | HEAD |
| Bottle Stable Root URL | https://ghcr.io/v2/homebrew/core |
| Deprecated | no |
| Disabled | no |
| Keg Only | no |
| URL Keys |
|
source trail
Generated from repository data
This page is generated by av-web from the private package SQLite artifact built by scripts/generate-pkg-sqlite.py.
Combined YAML source
View the package source record on GitHub.
Used sources
- Geiger risk classifier
- cross-ecosystem install command graph
- curated package history
- package relationship graph
- package version freshness
- package-page enrichment
- pkg.so package database
- pkgdb category and tag curation