macOS
Homebrewverified · 100%
brew install miniprotlocal Homebrew formula metadata
brew / rank 11998
Install miniprot with Homebrew
Align proteins to genomes with splicing and frameshift. Version 0.18 via Homebrew; verified from local package data.
install
Additional install commands
overview
Package summary
Align proteins to genomes with splicing and frameshift
Project links
Commands and aliases
- miniprot
history
Project history and usage
miniprot is Heng Li's protein-to-genome aligner for genome annotation. The preprint appeared in 2022 and the Bioinformatics paper was published in 2023, describing miniprot as a new aligner for mapping protein sequences to complete genomes with k-mer sketching and vectorized dynamic programming.
Project history
The program fills a bioinformatics gap between older tools such as GeneWise and Exonerate and the scale of modern genome projects. Its README says it aligns protein sequences against genomes with affine gap penalties, splicing, and frameshifts, primarily to annotate protein-coding genes in a new species using known genes from other species. It can build a genome index, output protein PAF, emit GFF3 with embedded PAF, and optionally use splice scores from minisplice.
How it is used
Adoption is source-backed through bioinformatics workflows rather than general-purpose package popularity. BUSCO's user guide lists miniprot among third-party tools to cite, and the GALBA genome-annotation pipeline paper describes genome annotation with miniprot and AUGUSTUS. Homebrew packages it as a single `miniprot` executable for the scientific-command-line niche, alongside Bioconda-style distribution and upstream source builds.
Sources
security posture
Risk level: green
narrow executable package without higher-risk signals.
Risk classifier
green risk · low confidence · appliance
Why
- narrow executable package without higher-risk signals
Signals
- metadata:no-higher-risk-signals
Install behavior
- No Homebrew bottle metadata was recorded.
Recommended review
Before unattended agent use, check whether the tool reads plaintext credentials, writes remote state, publishes artifacts, or shells out to plugins.
executables
Installed executables
| Command | Kind | Exposure | Note |
|---|---|---|---|
miniprot | executable | indexed executable | Discovered from the local executable index. |
freshness
Version and freshness
These signals separate page generation age, package-manager activity, and upstream release comparison. Version lag is warned only when an evidence URL and comparable versions are present.
page generated2026-08-03
manager version0.18
manager updated
local dataunknown
upstreamnot available
latest detectednot detected
- okNo freshness warnings were generated.
install metadata
Package metadata
| Package key | brew:miniprot |
|---|---|
| Version | 0.18 |
| Package manager | Homebrew |
| Homepage | https://lh3.github.io/miniprot/ |
| Repository | https://github.com/lh3/miniprot |
| Bottle | not recorded |
| Service | none declared |
source trail
Generated from repository data
This page is generated by av-web from the private package SQLite artifact built by scripts/generate-pkg-sqlite.py.
Combined YAML source
View the package source record on GitHub.
Used sources
- Geiger risk classifier
- cross-ecosystem install command graph
- curated package history
- pkg.so package database
- pkgdb category and tag curation