# Install miniprot with Homebrew Align proteins to genomes with splicing and frameshift. Version 0.18 via Homebrew; verified from local package data. ## Install ```sh sudo av install brew:miniprot ``` Additional install commands: ### macOS - Homebrew (100%): ```sh brew install miniprot ``` Evidence: local Homebrew formula metadata ## Package facts - **Package key:** brew:miniprot - **Package manager:** Homebrew - **Package manager page:** - **Version:** 0.18 - **Source summary:** Align proteins to genomes with splicing and frameshift - **Homepage:** - **Repository:** - **Upstream docs:** - **License:** MIT - **Source archive:** - **Generated:** 2026-08-04T22:13:35+00:00 ## Executables - miniprot (cli) - miniprot (alias) ## Install behavior - Post-install hook: not defined - Bottle: available on arm64_linux, arm64_sequoia, arm64_sonoma, arm64_tahoe, sonoma, x86_64_linux ## Freshness - Page generated: 2026-08-04 - Package-manager version: 0.18 - Local data: ok - Upstream repository: https://github.com/lh3/miniprot - Upstream latest detected: v0.18 (current) - info: No package-manager update timestamp was available. ## Project history and usage miniprot is Heng Li's protein-to-genome aligner for genome annotation. The preprint appeared in 2022 and the Bioinformatics paper was published in 2023, describing miniprot as a new aligner for mapping protein sequences to complete genomes with k-mer sketching and vectorized dynamic programming. ### Project history The program fills a bioinformatics gap between older tools such as GeneWise and Exonerate and the scale of modern genome projects. Its README says it aligns protein sequences against genomes with affine gap penalties, splicing, and frameshifts, primarily to annotate protein-coding genes in a new species using known genes from other species. It can build a genome index, output protein PAF, emit GFF3 with embedded PAF, and optionally use splice scores from minisplice. ### How it is used Adoption is source-backed through bioinformatics workflows rather than general-purpose package popularity. BUSCO's user guide lists miniprot among third-party tools to cite, and the GALBA genome-annotation pipeline paper describes genome annotation with miniprot and AUGUSTUS. Homebrew packages it as a single `miniprot` executable for the scientific-command-line niche, alongside Bioconda-style distribution and upstream source builds. ### Sources - - - - - - - ## Security Notes narrow executable package without higher-risk signals. - **Geiger risk:** green / low - narrow executable package without higher-risk signals ## Source Database Details - **Source Database:** Homebrew formula API - **Tap:** homebrew/core - **Full Name:** miniprot - **Version Scheme:** 0 - **Revision:** 0 - **Bottle Stable Root URL:** - **Deprecated:** no - **Disabled:** no - **Keg Only:** no - **URL Keys:** stable ## Related links - [Source-control packages](https://pkg.so/source-control-tools/) - Belongs to a source-control command family. - [Terminal utility packages](https://pkg.so/terminal-utilities/) - Matched terminal and command-line workflow metadata. - [Networking and protocol packages](https://pkg.so/networking-protocol-tools/) - Matched network, protocol, or remote-service metadata. - [Scientific computing packages](https://pkg.so/scientific-computing-tools/) - Matched scientific computing metadata. - [samtools](https://pkg.so/brew/samtools/) - Shares pkgdb curated category or tags: bioinformatics, cli, genomics, science. - [blast](https://pkg.so/brew/blast/) - Shares pkgdb curated category or tags: bioinformatics, cli, genomics, science. - [bedtools](https://pkg.so/brew/bedtools/) - Shares pkgdb curated category or tags: bioinformatics, cli, genomics, science. - [minimap2](https://pkg.so/brew/minimap2/) - Shares pkgdb curated category or tags: bioinformatics, cli, genomics, science. - [bbtools](https://pkg.so/brew/bbtools/) - Shares pkgdb curated category or tags: bioinformatics, cli, genomics, science. - [sambamba](https://pkg.so/brew/sambamba/) - Shares pkgdb curated category or tags: bioinformatics, cli, genomics, science. - [abricate](https://pkg.so/brew/abricate/) - Shares pkgdb curated category or tags: bioinformatics, cli, genomics, science. - [picard-tools](https://pkg.so/brew/picard-tools/) - Shares pkgdb curated category or tags: bioinformatics, cli, genomics, science. - [minigraph](https://pkg.so/brew/minigraph/) - Local package facts share a topical domain. Shared terms: bioinformatics, cli, genomics, mapping, science. - [mummer](https://pkg.so/brew/mummer/) - Local package facts share a topical domain. Shared terms: alignment, bioinformatics, cli, genomics, protein. ## Combined YAML source View the package source record on GitHub. [combined/miniprot.yml](https://github.com/mxcl/pkgdb/blob/main/combined/miniprot.yml) ## Sources - pkg.so package database - Geiger risk classifier - package-page enrichment - curated package history - package version freshness - pkgdb category and tag curation - package relationship graph - cross-ecosystem install command graph